Cholesterol and the cell membrane. Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 822(3-4), 267-287. 3. Miller, W. L., & Auchus, R. J. (2011). The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders. Endocrine Reviews, 32(1), 81-151. 4. Holick, M. F. (2007). Vitamin D deficiency. New England Journal of Medicine, 357(3), 266-281. 5.Russell, D. W. (2003). The enzymes, regulation, and genetics of bile acid synthesis. Annual Review of Biochemistry, 72, 137-174. 6.Istvan, E. S., & Deisenhofer, J. (2001). Structural mechanism for statin inhibition of HMG-CoA reductase. Science, 292(5519), 1160-1164. 7. Chapman, M. J., et al. (2011). HDL in the prevention of atherosclerotic cardiovascular disease. European Heart Journal, 32(11), 1345-1360. 8. Goldstein, J. L., & Brown, M. S. (2015). A century of cholesterol and coronaries: from plaques to genes to statins. Cell, 161(1), 161-172. 9.Brown, L., et al. (1999). Cholesterollowering effects of dietary fiber: a metaanalysis. The American Journal of Clinical Nutrition, 69(1), 30-42. 10. Libby, P. (2002). Inflammation in atherosclerosis. Nature, 420(6917), 868-874. 11. Saher, G., et al. (2005). High cholesterol level is essential for myelin membrane growth. Nature Neuroscience, 8(4), 468-475. 12. Seidah, N. G., & Prat, A. (2012). The biology and therapeutic targeting of the proprotein convertases. Nature Reviews Drug Discovery, 11(5), 367-383. 13. Ridlon, J. M., et al. (2014). Gut microbiota production of bile acids. Gut Microbes, 5(4), 455-462. Kapitola: Co je cholesterol? 800 182 572 7:30-16:30 (Pá: do 14:00) Vyhlídka 39, 63800 Brno, Česká republika Tel: +420 545 222 863 Fax: +420 545 222 011 www.vitaminy-mineraly.cz Strana 15 Graf znázorňuje, jak je cholesterol rozdělen v různých tkáních lidského organismu. Největší podíl se nachází v buněčných membránách, které tvoří více než polovinu veškerého cholesterolu v těle.
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